With the continuous development of molecular biological engineering, fermentation tanks have provided a wider field for the breeding of excellent bacteria, and replaced by genetically recombinant strains, which have been reported in the original citric acid and penicillin strains.

Genetic engineering means to transform traditional fermentation industry, which is not a long way off. If we do not work hard, the technological advantages of molecular bioengineering are likely to be lost in the new round of competition. As the fermentation tank becomes larger and larger, the contradiction between it and the preparation of the manual bran is becoming more and more prominent, how to realize the industrialization of the preparation of the gluten, or to replace it with spore powder, is a difficult problem that has not been solved for many years. Naturally, it is most desirable to produce spores or immobilized technology, but with high technical difficulty. At present, it is more realistic to use solid fermentation to change the backward production process. Now the solid fermenter has been published, and there have been reports on the application of bio-pharmaceutical, enzyme preparation, production and other industries. It is a vertical multi-layer solid fermenter, which can be sterilized by feeding forward. The material is made from the top feeding hole, and then it is steamed and sterilized. The material is cooled by the inner tube and the external jacket, and the bottom of the tank enters the sterile air, which is discharged from the top of the tank to achieve the requirements of ventilation and constant temperature. The axial mixing is used to turn the material, and the volume range of the fermentation tank is 0.5 ~ 10m3. Another kind of intelligent life fermentation tank of east China university of science and technology has a full capacity of 50L ~ 5000L, which adopts the stirring method of external tank rotation. The material can be sterilized by steam sterilization inside the tank, and the temperature and humidity in the inlet can be adjusted to 0 ~ 30rmp, all of which are stainless steel structure. Using these solid-state fermentation tanks to reform our traditional gluten preparation, the hope for success would be huge.

When the large exhaust valves of solid fermenters were selected, researchers felt the problem was a challenge; Due to the large amount of the intake and outlet of the large tank, it is generally more than 10 inches. At this time, the price of single seat regulating valve is relatively high, and the investment is relatively large, which is only a better control effect. The single valve can hardly meet the requirements of asepsis. The fireproof butterfly valve and positioner can be used to select the butterfly valve. This advantage is that the investment can be reduced. Because of the steam killing bacteria, the average stainless steel butterfly valve is hard to satisfy 120 degrees of heat, and you can only choose the product of a well-known brand, like KESTONE, BRAY, and so on. Adjust butterfly valve because the connection between actuator and valve belongs to a loose shaft key connection, so the valve switch often exists in the dead zone of control, especially after use for a period of time, the control effect may be slightly worse, but it can also meet the production needs. It is therefore recommend to regularly check that replacement of the connected shaft key.